Wine is many kinds of favorite food that people use very for a long time. Some people praise wine and others people refuse. Like this, there were a lot of side effects as the history. So, I will search ambiguity of wine in two sides here. First, it is advantage of wine. It is very famous doctor that Greek Hippocrates speaks “Wine have value most as drink, and tastes most as medicine, and amuse most among food “ 2700 old years ago. In this way, wine has considered by efficacious medicine from ancient. Nowadays doctors certified truth that suitable drinking protects heart disease. There was report of this truth that it is good for metabolism and act as digestive. Also, it is peddler’s secret and profitable in person’s mind health. For example, It makes personal relations smooth being in civil life.But, there were a lot of side effects as the history. Wine have tried to control mankind if is an opportunity. A person who wield for wine suffer from alcoholism or drinking affects in all important special skills of human body such as central nervous system, endocrine system m stomach heart pipe, and so on. And In spiritual a side, it can cause home disagreement because does individual’s spiritual and physical fitness by contradictory value, and deal harm that is great on company or whole society. Like this, wine has various ambiguities. But, there is a common in such various ambiguities. According to use it, it is effective as medicine or becomes harmfulness. So, we have grasp ambiguity of wine certainly and use to only good side.